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Epileptic Brain

Development of the nonlinear dynamical and global optimization techniques to completely characterize the brain’s spatiotemporal dynamics during the transition to epileptic seizures in humans and rodent models:

  • At the macroscopic (EEG and field potential) level.
  • At the microscopic (AP trains) level using in vitro hippocampal slices and measuring individual firing of neurons under various conditions (e.g. low-Ca2+).

This research will involve scientists from Basic Neuroscience, Clinical Neurophysiology and Signal Processing (including pattern recognition, system modeling and optimization), Circuitry and Instrumentation

Research Approach

  • Identification of seizure precursors in “status epilepticus” and hyperthermia induced febrile seizures
  • Modeling of the epileptic transition via nonlinear chaotic models and neural networks.
  • Control of the epileptic transition
  • Design and development of a microdevice to intervene and abort epileptic seizures in real time.